Advanced Glycation Endproducts (AGE)

• When proteins are exposed to elevated levels of glucose the

following series of non-enzymatic chemical reactions occur

3 Gycation of proteins and formation of both Amadori adducts

and AGE compounds can have biological consequences

hours

days

weeks

Rearrangement

Cross-linking

Glucose

+

Protein-NH2

Glycated

proteins

(Schiff Base)

Amadori

Adducts

AGEs

Cell activation

Tissue structural changes

Glycation

Diapositiva anterior

Diapositiva siguiente

Ir a la primera diapositiva

Ver versión gráfica