"GLOMERULAR FILTRATION RATE (GFR) ESTIMATED FROM MDRD STUDY COMPARED WITH OTHERS RENAL FUNCTIONAL PARAMETERS IN ELDERLY DIABETICS PATIENTS ON PREDIALYSIS UNIT"

S. Cigarrán, G. Barril, R.Selgas

Unidad de Predialisis. Servicio de Nefrología. Hospital de la Princesa. Madrid. ESPAÑA
cigarran@ctv.es

GFRE is traditionally considered the best overall index to determine renal function in health and disease, being Cockcroft y Gault formula more widely used to predict it. Recently MDRD study developed a new formula, more accurate to evaluate GFR, based on age, sex, gender,height, serum creatinin, serum BUN and serum Albumin. But this study has not been tested in elderly and diabetic patients with CRI.The performance of GFR derived from MDRD in subgroup of diabetics and elderly patients with CRI and compare with others indexes was the aim of the study.

23 pts diabetics were studied in our PreESRD unit Mean age ( x¯)= 71.09 ± 12.68 yr, 12 M, 11 W, included with CrClbs <30 ml/min/1.73m2 . ICDE 2.57±0.79. Parameters analyzed were , age, gender, weight, sex, height, serum Cr, serum Albumina , serum BUN, urine BUN, urine Cr , diuresis and proteinuria. Data were processed and stadistically analyzed with SPSS 10.0 software package. The relation of renal function measurements to other baseline characteristics was assessed by using contingency tables, t-tests, analysis of variance and linear regression, as appropiate. A P value less than 0.01 was considered statistically significant. We used stepwise multiple regression to determine a set of variables that predicted GFR.

Descriptive parameters of renal function were:

N

Minimum

Maximum

Mean ± SD

CrClbs

26

6.10

35.9

18.5 ± 8.05

GFR MDRD

26

6.5

24.6

14.3 ± 4.5

KT/V wk

26

0.8

3.3

1.9± 0.7

GFRE

26

4.8

23.2

11.9 ± 4.9

Linear regression results were

  GFR- MDRD relationship
Regre
Coeff. (ß); 		P; R2
CrClbs; 0.94; <0.01; 0.89
GFRE; 0.78; <0.01; 0.61
Kt/V wk; 0.57; <0.01; 0.33


Conclussions: GFR index derived from MDRD study has a strong positive correlation with others indexes used to predict renal function, specially with CrClbs. Also is specially usefull to predict the GFR in elederly diabetics subgroup of patients and/or with disorders associated in which others indexes are not easy to perform.