Osmolality and Biocompatibility

•

•

•

•

% Phagocytosis

80

40

0

275

375

475

mOsm/kg

Duwe et al., Infect Immun, 1981

• Numerous publications have shown that hyperosmolality,

mainly seen with 3.86% glucose, can affect

cell structure and function

• This pioneering study by Duwe et al. shows the
  gradual inhibition of PMN phagocytic capability
  with increasing osmolality

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