RENAAL Study Design

Data on file, MSD

*CT=conventional therapy: Open-label calcium channel blocker, diuretic, beta-blocker or alpha- blocker.

4 Wks

Losartan 100 mg qd

(+CT)

Maintain conventional

antihypertensive therapy (CT)*

(excluding ACEi, AIIA)

Losartan 100 mg qd (+CT)

Placebo

(+CT)

Goal trough BP:

< 140/៊ mmHg

n=1513

Placebo (+CT)

Losartan 50 mg qd

(+CT)

Placebo

(+CT)

8 Wks

6 Wks

Average follow-up 3.4 years