Diapositiva PPT

COX-2

AA

PG

PG

Autocrine

Paracrine

COX-1

AA

PG

PG

Autocrine

Neighbour Cell

Epithelial cell

COX 1 & 2 are involved in autocrine and paracrine ways of signaling

involving G-protein coupled receptors and PPRAa, b & g

Constitutive

Inducible by cytokines through C/EBP-NF-IL-6, CRE, NF-kB, & SP1 sites

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