Diapositiva PPT

Examples of scaffold proteins and

signaling complexes in mammalian cells

MP1 (MEK partner 1)

JIP-1 (JNK interacting protein 1)

JIP-1

JNK

MKK7

MLK

HPK

Whitmarsh et al.,

Science, 281,1671,1998

IkB kinase signalsome complexes

contain IkB kinase a and b and

in some cases other proteins as

MEKK1, IKK-associated protein 1,

and Tax

HPK, hematopoietic progenitor kinase 1

MLK, mixed lineage kinase

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