Síndrome MetabólicoPerspectiva

Adapted from Reaven G. Drugs. 1999;58 (suppl):19-20

Tamaño

? IMC

? Adiposidad Intrabdominal

Metabolismo

Glucosa

Metabolismo

Ac.Úrico

Dislipidemia

Hemodinamica

Nuevos FRC

ENFERMEDAD CORONARIA

Resistencia Insulinica

Hiperinsulinemia

+

• ? TG

• ? PP lipemia

• ? HDL-C

• ? PHLA

• Small, dense LDL

• ±intolerancia

a Glucosa

• ? A.Úrico

• ? Aclramiento

Urinario de Ac ürico

• ? Actividad SNS

• ? Retention Na

• Hipertension

• ? CRP

• ? PAI-1

• ? Fibrinogen

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The metabolic syndrome: current perspective

Since the 1998 Banting lecture, a number of new candidates have been recognized for the metabolic syndrome/insulin resistance syndrome/syndrome “X”. These additional candidates have included small dense LDL and a group of novel risk factors including elevated CRP levels, PAI-1 and fibrinogen. Other investigators have noted that insulin resistance occurs in women with polycystic ovarian syndrome and some authors are now making an association of insulin resistance with non-alcoholic fatty liver disease. Note that in this more recent review, Professor Reaven acknowledges the importance of visceral adiposity.

References:

1. Reaven G. Syndrome X: 10 years after. Drugs. 1999;58(suppl 1):19-20.