HOPE: ACE Inhibitors in PatientsWith Atherosclerosis or Diabetes

Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000;342:145-153.

Percent With an Event

Revascularization

DM

Complications

HF

Hospitalizations

HeartFailure

New Diagnosis of

Diabetes Mellitus

16%

P=0.03

12%

P=0.25

23%

Pɘ.001

34%Pɘ.001

15%Pɘ.002

16

6.4

3

9

3.6

18.3

7.6

3.4

11.5

5.4

0

5

10

15

20

25

Risk Reduction

Placebo

Ramipril

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