Angiotensin II effects at the AT1 and AT2 receptors
Adapted from McConnaughey et al. J Clin Phamacol 1999;39: 547–59.
Activate sympathetic activity
Increase sodium retention
Increase vasopressin release
Promote myocyte hypertrophy and proliferation
Stimulate vascular and cardiac fibrosis
Stimulate plasminogen activator inhibitor 1
Stimulate superoxide formation
Vasodilation (NO mediated?)
Stimulate renal bradykinin and NO