Mechanistic Rationale for RAS Blockade in Diabetic Renal Disease

Valentino VA et al. Arch Intern Med 1991;151:2367-2372.

Dilation of Efferent Arteriole Only

Glomerulus

Bowman’s

capsule

Afferent

arteriole

Efferent

arteriole

¯ Glomerular pressure

¯ Albumin excretion rate