Course of diabetic renal disease

140

160

100

120

60

80

20

40

0

4

1

3

2

GFR

(ml/min)

Protein

excretion

(g/day)

Pre-clinical

Diabetic Renal Disease

Overt Proteinuria

Micro-

albuminuria

Proteinuria

Persistent

Microalbuminuria

Adapted from Mogensen CE. Kidney Int 1982;21:673.

and Friedman EA. Kidney Int 1982;21:780.

Time (yrs 10)

0

20

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