Paper # 096 Versión en Español Spanish version

Thymic microenvironmental changes in human congenital syphilis

Eliene C. Fonseca, Mônica P. Almeida, Évlin H. Maia, Dora M. F. Menezes and Wilson Savino*

[Title] [Introduction] [Materials and Methods] [Results] [Discussion] [Pictures]

Discussion

Next Paper

BIBLIOGRAPHY

 

  1. Aguilar LK, Aguilar-Cordova E, Cartwright J Jr & Belmont JW : Thymic nurse cells are sites of thymocyte apoptosis.J. Immunol 152 : 2645, 1994.
  2. Anderson SJ & Perlmutter RM : A signaling pathway governing early thymocyte maturation. Immunol. Today 16(2) : 99, 1995
  3. Asma GEM, Van Den Bergh & Vossen JM : Use of monoclonal antibodies in a study of the development of T lymphocytes in the human fetus. Clin. Exp. Immunol. 53 : 429, 1983.
  4. Baughn RE, McNeely MC, Jorizzo JL & Musher DM : Characterization of the antigenic determinants and host components in immune complexes from patient with secondary syphilis. J. Immunol. 136(4) : 1406, 1986.
  5. Baughn RE: Role of fibronectin in the pathogenesis of syphilis. Rev. Inf. Dis. 9(suppl.4) : 374, 1987.
  6. Berrih S, Savino W & Cohen S : Extracellular matrix of the human thymus: immunofluorescense studies on frozen sections and cultured epithelial cells. J. Histochem. Cytochem. 33(7) : 655, 1985.
  7. Boyd R.L. & Hugo P.: Towards an integrated view of the thymopoiesis. Immunol. Today 12: 71, 1991.
  8. Boyd R.L., Tucek C.L., Goldfrey D.I., Izon D.J., Wilson T.J., Davidson N.J., Bean A.G.D., Ladyman H.M., Ritter M.A. & Hugo P.: The thymic microenvironment. Immunol. Today 14(9): 445, 1993.
  9. De Souza M., Tilney N.L. & Kupiec-Weglinski J.W. : Recognition of self within self specific lymphocyte positioning and extracellular matrix. Immunol. Today 12: 262, 1991.
  10. Fitzgerald TJ, Repesh LA, Blanco DR & Miller JN: Attachment of treponema pallidum to fibronectin, laminin, collagen IV and Collagen I, and blockage of attachment by immune rabbit IgG. J. Vener. Dis. 60: 357, 1984
  11. Fitzgerald TJ & Repesh LA: Interactions of fibronectin with Treponema pallidum. Genitourin. Med. 61: 147, 1985
  12. Fonseca E.C., Chammas R., Brentani R.R. & Savino W. : Co-cultures of fibroblats and epithelial cell lines: a model to study thymocyte-stromal cell interactions. 2nd Brazilian Symposium on Extracellular Matrix (Resumos).Campos do Jordão-SP, 1992.
  13. Fonseca E.C., Villa-Verde D.M., Lannes-Vieira J. & Savino W. : Thymic extracellular matrix in Down’s syndrome. Braz. J. Med. Biol. Res. 22: 971, 1989.
  14. Haynes BF : The role of the thymic microenvironment in promotion of early stages of human T cell maturation. Clin. Res. 34: 422, 1986.
  15. Krugman S, Katz SL, Gershon AA & Wilfert CM: Sexually transmittable diseases in children. In Infectious Diseases of Children, 9th edition, 1992.
  16. Lannes-Vieira J, Cirne-Lima EO & Savino W : Hidrocortisone modulates cytokeratin and extracellular matrix expression by the thymic microenvironment. Ann. N. Y. Acad Sci. 650: 85, 1992.
  17. Lannes-Vieira J, Vanier-Santos M, Brentani RR & Savino W : Intra-thymic modulation of the CD3 complex and T cell receptor expression by in vivo injection of anti-fibronectin antibodies. In press.
  18. Lannes-Vieira J, Van der Meide PH & Savino W : Extracellular matrix components of the mouse thymic microenvironment. II. In vitro modulation of basement membrane proteins by interferon-gamma: relationship with thymic cell proliferation. Cell Immunol. 137 : 1, 1991.
  19. Le PT, Kurtzberg J, Brandt SD, Niedel JE, Haynes BF & Singer KH : Thymic epithelial cell produce granulocyte and macrophage colony stimulating factors. J. Immunol. 141 : 1211, 1988.
  20. Martin-Fontecha A, Schuurman HJ & Zapata A : Role of thymic stromal cells in thymocyte education : A comparative analysis of different models. Thymus 22: 201, 1994.
  21. Meireles-de-Souza L.R., Trajano V. & Savino W. : Is there an interspecific diversity of the thymic microenvironment? Dev. Immunol. 2: 51, 1992.
  22. Montes GS & Junqueira LCU: The use of the Picrosirius - polarization method for the study of the biopathology of collagen. Mem. Inst. Oswaldo Cruz, 1992.
  23. Numazaki K., Goldman H., Bai X.-Q., Wong I. & Wainburg M.A. : Effects of infection by HIV-1, cytomegalovirus and human measles virus on cultured human epithelial cells. Microbiol. Immunol. 33(9): 733, 1989.
  24. Ocampo-Lyra J.S.P., Madi K., Maeda C.T. & Savino W.: Thymic extracellular matrix in human malnutrition. J. Pathol, 171(3) : 231, 1993.
  25. Ouaissi MA: Role of RGD sequence in parasite adhesion to host cells. Parasitol. Today 4: 169, 1988.
  26. Owen JJT & Moore NC : Thymocyte-stromal-cell interactions and T-cell selection. Immunol Today 16(7) : 336, 1995.
  27. Reza JN & Ritter MA : Differential expression of adhesion molecules within the human thymus. Dev. Immunol. 4: 55, 1994
  28. Ritter M.A. & Boyd R.L.: Development in the thymus: It takes two to tango. Immunol. Today 14(9): 462, 1993.
  29. Savino W.: The thymic microenvironment in infectious diseases. Mem. Inst. Oswaldo Cruz 85: 255, 1990.
  30. Savino W &Berrih S: Thymic extracellular matrix in myasthenia gravis. Lancet ii : 65, 1984.
  31. Savino W., Dardenne M., Marche C., Trophilme D., Dupuy J-M., Pekovic D., Lapointe N. & Bach J-F.: Thymic epithelium in AIDS: an immunohistologic study. Am. J. Pathol. 122: 302, 1986.
  32. Savino W & Dardenne M : Imunne-neuroendocrine interactions. Immunol. Today 16(7) : 318, 1995.
  33. Savino W & Dardenne M : Thymic hormones containing cells. IV- Immunohistology evidence for the simultaneous presence of thymulin, thymopoietin and thymosin alfa-1 in normal and pathological human thymus. Eur. J. Immunol. 14: 987, 1984.
  34. Savino W. & Lannes-Vieira J.: Is there a role for extracellular matrix in thymus physiology and pathology? Mem. Inst. Oswaldo Cruz 86 suppl 3: 109, 1991.
  35. Savino W., Leite de Morais M.C., Silva Barbosa S.D., Fonseca E.C., Cotta-de-Almeida V. & Hontebeyrie-Joscowics M.: Is the thymus a taget organ in infectious diseases? Mem. Inst. Oswaldo Cruz, 87(suppl.5) : 73, 1992.
  36. Savino W., Villa-Verde D.M. & Lannes-Vieira J.: Extracellular matrix proteins in intrathymic T-cell migration and differentiation. Immunol. Today 14(4): 158, 1993.
  37. Shimizu Y & Shaw S : Lymphocyte interactions with extracellular matrix. FASEB J. 5: 2292, 1991
  38. Schuppan D & Rugl M : Matrix in signal transduction and growth factor modulation. Brazillian J. Med. Biol. Res. 27 : 2125, 1994.
  39. Singer K.H. & Haynes BF : Epithelial and thymocyte interactions in human thymus. Human Immunol. 20: 127, 1981.
  40. Singer K.H. & Haynes BF : Interactions between epithelial cells and T lymphocytes: role of adhesion molecules. J. Leuk. Biol. 48 : 367, 1990
  41. Sutsumi K., Sawada M., Narumiya S., Nagamine J., Sakata T., Iwagami S., Kita Y., Teraoka H., Hirano H., Agata M., Hamaoka T. & Fugiwara H. : Adhesion of immature thymocyte to thymic stromal cells though fibronectin molecules and its significance for the induction of thymocyte differentiation. Proc. Natl. Acad. Sci. USA 88: 5685, 1991.
  42. Van-Baarlen J, Schuurman HJ & Huber J : Acute thymus involution in infancy and childhood: a reliable marker for duration of acute illness. Hum. Pathol. 19(10) : 1155, 1988.
  43. Villa-Verde DM, Lagrota-Candido JM, Vannier-Santos MA, Chammas R, Brentani RR & Savino W : Extracellular matrix components of the mouse thymus microenvironment. IV- Modulation of thymic nurse cells by extracellular matrix ligands and receptors. Eur. J. Immunol. 24(3) : 659, 1994.
  44. Villa-Verde DM & Savino W : Thymic "nurse" cells express extracellular matrix proteins. Mem. Inst. Oswaldo Cruz 86(suppl.3) : 109, 1991

 

Discussion

Next Paper