Results. Paper # 096

Paper # 096

Versión en Español

Thymic microenvironmental changes in human congenital syphilis

Eliene C. Fonseca, Mônica P. Almeida, Évlin H. Maia, Dora M. F. Menezes and Wilson Savino*

[Title] [Introduction] [Materials and Methods] [Discussion] [Pictures] [Bibliography]

RESULTS

Thymic Pathology :

Organ atrophy
Thymocyte depletion
Intra-thymic B cells
Changes in ECM
Altered pattern of cortical and medullary TEC network
Extramedullary hematopoiesis

Thymic Extracellular matrix :

Septal space enlargement
Thickened basement membrane
Basement membrane Ig deposits
Novel intraseptal space
Intralobular ECM expression

Lymphocyte depletion X Septal enlargement

Cases	Sex	Age	* Lymphocyte depletion	**Septal enlargement
1	M	Stillborn	+++	++++
2	M	Stillborn- 28wk	+++	++++
3	F	Stillborn- 35 wk	+++	++++
4	M	Stillborn- 32 wk	+++	+++
5	F	Stillborn- 26 wk	+++	+++
6	F	Newborn	+++	+++
7	F	Newborn- 35 wk	++	++
8	M	Stillborn - 24 wk	++	+
9	M	Stillborn - 37 wk	+	+
10	F	Stillborn	++	0
11	M	Stillborn - 27 wk	+	++
12	M	Newborn -33 wk	+	0
13	M	Stillborn	+	+
14	F	Newborn- 35 wk	+	0

* Lymphocyte Depletion
+ mild
++ moderate
+++ severe

** Septal enlargment
0 normal
+ mild
++ moderate
+++ severe, without septal "projections"
++++ severe, with septal "projections"