Paper # 008

Versión en Español

Purkinje cell hamartoma (Histiocytoid cardiomyopathy). Study of a case in an 18 months infant.

Marcial Garcia-Rojo, Carlos Gamallo, Felipe Moreno

[Title] [Introduction] [Materials and Methods] [Pictures] [Discussion] [Bibliography]

RESULTS

The histological examination of the lesion showed large polygonal cells, that were mainly located in the subendocardium. These cells had large amount of cytoplasm, that was clear and with PAS positive inclusions, and with irregular nuclei (fig. 1).

Fig. 1. PAS x 200

With PTAH (Phosphotungstic acid hematoxylin) stain, a lack of striations was observed in the cells that were part of the lesion. However, normal muscle fibers showed a normal pattern of stainning (figs. 2 y 3).

Fig. 2. PTH x 40

Fig. 3. PTH x 200

Ultrastructurally, a large amount of mitochondria were found.

Inmunohistochemistry

• Contraction proteins
• Calmodulin
• Collagen IV

• Title
• Introduction
• Materials & Methods
• Pictures
• Discussion
• Bibliography